It was morning when the man was pulled over by the police who assumed he was driving under the influence.
His blood alcohol level was found to be more than twice the legal limit – 200 milligrams per 100ml of blood (200mg/dL). Singapore’s legal drink-driving limit is strictly enforced at 80mg/dL, or 0.08 per cent blood alcohol content.
The man, who was 46 at the time of the incident in 2014, also experienced brain fog, dizziness and memory loss – much like the symptoms an alcoholic exhibits.
But he told the police that not a drop of alcohol had ever passed his lips.
It was only after multiple consultations with various doctors in different specialities over a few years that he was diagnosed with auto-brewery syndrome (ABS). The case was documented in a 2019 report in BMJ Open Gastroenterology, an online-only, peer-reviewed, open access journal.
ABS, which is also known as gut fermentation syndrome, is an extremely rare condition where bacteria and fungi in the gastrointestinal tract turn the carbohydrates in everyday foods into alcohol.
If left untreated, it can lead to non-alcoholic fatty liver disease.
There were fewer than 100 cases of ABS reported worldwide in a 2021 report, with the man being the only known case in Singapore. His doctors declined to identify him.
Different ABS patients have different triggers for the condition. For the Singapore man, his doctors believe the antibiotics he took for a thumb injury was his trigger.
Dr Jonathan Lee, a senior consultant from the Division of Gastroenterology and Hepatology at the Department of Medicine in the National University Hospital (NUH), said when there is too much carbohydrates, the gut of someone with ABS converts them into alcohol.
When the liver is unable to digest or metabolise every bit of carbs into energy for the body, alcohol builds up in the blood, producing the same effects as drinking too much.
According to the BMJ study, the Singaporean man with ABS, who is now in his 50s, started having dizziness, brain fog, memory loss and aggression issues in 2011, about a week after he completed a round of antibiotics for the thumb injury.
Unable to figure out what was wrong with himself, he consulted various doctors in different specialities over the span of a few years but none of them could diagnose his condition.
He was even referred to a psychiatrist, who prescribed antidepressants, but that did not help his symptoms.
He went for more tests and eventually doctors found in his stool sample the fungus saccharomyces cerevisiae, also known as brewer’s yeast, a one-celled fungus used in making top-fermenting beer.
He was prescribed anti-fungal medication and told to stop eating carbs, but that did not work.
Eventually, he went to see Associate Professor Dan Yock Young, a senior consultant gastroenterologist at the Department of Medicine in the NUH.
“He exhibited intermittent unexplained debilitating symptoms, which suggested an organic cause. We screened him for metabolic causes and found that blood alcohol levels were raised, despite no history of alcohol intake,” Prof Dan told ST.
Dr Lee, who was among doctors at NUH to treat the man, said: “On top of that, he had bloating, which was similar to another medical condition called Sibo, or small intestinal bacterial overgrowth. (He) had the symptoms of bacterial overgrowth, which improved (only) a little bit when we treated (him) with a course of antibiotics.”
The doctors were also looking at faecal microbiota transplant as the last resort. This is a medical procedure to treat a severe bacterial infection in the colon – faecal matter from a healthy donor is processed and administered into a patient’s gastrointestinal tract to stabilise the microbiome by reintroducing beneficial microbes.
It involves transferring the entire gut ecosystem from a healthy donor to a patient.
In the end, it took the team “about three to six months before we suspected, tested for and diagnosed the patient with ABS”, Prof Dan said.
The man was given a combination of antibiotics and anti-fungal medicines “based on culture and sensitivity results for the identified yeast and bacteria”, as well as probiotics to treat his condition.
He was also told to avoid simple carbohydrates such as sugars and refined foods, and to maintain a low-sugar diet, Dr Lee said.
This meant he had to avoid consuming sodas, juice, fruit, flour, pastries, bread, alcoholic beverages, and even certain “health” foods such as kimchi, sauerkraut, yogurt, kefir and kombucha – all of which may worsen the condition since these fungi in the gut proliferate by feeding on these foods and drinks.
Instead, he had to take a high-fat, very low-carb diet until the bacterial and fungal levels normalised and symptoms resolved in a few weeks.
Dr Lee said eating the right food groups in the right order also helps keep ABS symptoms at bay.
“If you were to eat high fibre first, you actually cut down the digestion of sugars because the microbes and enzymes are all targeting the fibre,” he added.
Prof Dan said while the prognosis of this patient was good, “as symptoms were ameliorated through diet management and treatment… achieving a long-term cure is uncertain”.
“But I believe he felt vindicated by the diagnosis, knowing that his symptoms were real. He has achieved good results with treatment, though there were episodes of relapse,” he said.
The patient has also since given up driving, Prof Dan added.
Man who doesn’t drink alcohol gets drunk eating carbs, Latest Singapore News
